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Bardoxolone
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Bardoxolone

CAS: 218600-44-3

Ref. TR-B118660

1mg
109.00 €
5mg
381.00 €
10mg
679.00 €
Estimated delivery in United States, on Tuesday 10 Dec 2024

Product Information

Name:
Bardoxolone
Controlled Product
Synonyms:
  • CDDO
  • RTA 401
  • 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid
  • 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid
Description:

Applications Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events.
References Shepler, B., et al.: Clinical. Therap., 34, 1237 (2012); Speranza, G., et al.: Cancer. Chemo. Pharmacol., 69, 431 (2012); Sporn, M.B., et al.: J. Natural. Prod., 74, 537 (2011);

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:

Chemical properties

Molecular weight:
491.66
Formula:
C31H41NO4
Color/Form:
Neat
SMILES:
CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](C(=O)C=C4[C@@]3(C)CC[C@H]3C(C)(C)C(=O)C(C#N)=C[C@]43C)[C@@H]2C1
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Hazard Info

UN Number:
EQ:
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Forbidden to fly:
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