Product Information
Name:BAY 11-7082
Controlled Product
Synonyms:
- (E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
- (E)-3-(p-Tolylsulfonyl)-acrylonitrile
- BAY 11-7821
- BAY 117821
Brand:TRC
Description:Applications BAY 11-7082 is a nuclear factor-κB (NF-κB) inhibitor and a potential anti-inflammatory agent. It selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of Iκβα without affecting constitutive Iκβα phosphorylation. Potent IKK inhibitorReferences Pierce, J.W., et al.: J. Biol. Chem., 272, 21096 (1997); Keller, S.A., et al.: Blood, 96, 2537 (2000); Remacle-Bonnet, M.M., et al.: Cancer Res., 60, 2007 (2000); Thévenod, F., et al.: J. Biol. Chem., 275, 1887 (2000); Petegnief, V., et al.: Neuroscience, 104, 223 (2001); Kauppinen, T.M., et al.: J. Immunol., 174, 2288 (2005)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:207.25
Formula:C10H9NO2S
Color/Form:Neat
InChI:InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InChI key:InChIKey=VUSBHGLIAQXBSW-UHFFFAOYSA-N
SMILES:C=CC(C)CC(=O)CC(C)C
Technical inquiry about: BAY 11-7082
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