cis-4-[[2-(1H-Benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol

CAS: 1792999-26-8

Ref. TR-B197005

Product Information

• Name: cis-4-[[2-(1H-Benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol
• Synonyms: NCB-0846
• Brand: TRC

Description

Applications cis-4-​[[2-​(1H-​Benzimidazol-​6-​ylamino)​-​8-​quinazolinyl]​oxy]​-​cyclohexanol inhibits Traf2 and Nck-interacting protein kinase (TNIK). TNIK is involved with Canonical Wnt/b-catenin signalling, which has regulatory roles in maintaining intestinal stem cells and aberration in this pathway has been implicated in colorectal carcinogenesis. TNIK is a therapeutic target.
References Masuda, M., et al.: Nat Commun. 7, 12586 (2016); Masuda, M., et al.: Pharmacol. Ther. 156, 1 (2017);

Chemical properties

• Molecular weight: 375.42
• Formula: C₂₁H₂₁N₅O₂
• Color/Form: Neat
• InChI: InChI=1S/C21H21N5O2/c27-15-5-7-16(8-6-15)28-19-3-1-2-13-11-22-21(26-20(13)19)25-14-4-9-17-18(10-14)24-12-23-17/h1-4,9-12,15-16,27H,5-8H2,(H,23,24)(H,22,25,26)
• InChI key: InChIKey=FYWRWBSYRGSWIQ-IYBDPMFKSA-N
• SMILES: O[C@H]1CC[C@@H](Oc2cccc3cnc(Nc4ccc5nc[nH]c5c4)nc23)CC1