N4-Benzoyl-2’-deoxy-5’-O-DMT-cytidine 3’-CE Phosphoramidite

CAS: 102212-98-6

Ref. TR-B207930

Product Information

• Name: N4-Benzoyl-2’-deoxy-5’-O-DMT-cytidine 3’-CE Phosphoramidite
• Synonyms: N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-cytidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite], N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite], DMT-​dC(bz) Phosphoramidite
• Brand: TRC

Description

Applications N4-Benzoyl-2’-deoxy-5’-O-DMT-cytidine 3’-CE Phosphoramidite is used to prepare antisense oligonucleotides containing conformationally constrained methoxyaminomethylene and aminooxymethylene and aminomethylene bridged nucleoside analogs.
References Prakash, T., et al.: J. Med. Chem., 53, 1636 (2010); Winkler, J., et al.: Eur. J. Med. Chem., 44, 670 (2009)

Chemical properties

• Molecular weight: 833.91
• Formula: C₄₆H₅₂N₅O₈P
• Color/Form: Neat
• InChI: InChI=1S/C46H52N5O8P/c1-32(2)51(33(3)4)60(57-29-13-27-47)59-40-30-43(50-28-26-42(49-45(50)53)48-44(52)34-14-9-7-10-15-34)58-41(40)31-56-46(35-16-11-8-12-17-35,36-18-22-38(54-5)23-19-36)37-20-24-39(55-6)25-21-37/h7-12,14-26,28,32-33,40-41,43H,13,29-31H2,1-6H3,(H,48,49,52,53)/t40-,41+,43+,60?/m0/s1
• InChI key: InChIKey=LGIRBUBHIWTVCK-UHFFFAOYSA-N
• SMILES: Clc1cc2c(c(Cl)c1Cl)Oc1c(cc(Cl)c(Cl)c1Cl)O2