Product Information
Name:4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Controlled Product
Synonyms:
- TDZD 8 - Bio-X ™
Brand:TRC
Description:
Applications Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3ß ( IC50 =2nM). Binds to the active site of GSK-3ß. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM).
References Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:222.26
Formula:C10H10N2O2S
Color/Form:Neat
InChI:InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
InChI key:InChIKey=JDSJDASOXWCHPN-UHFFFAOYSA-N
SMILES:Cn1sc(=O)n(Cc2ccccc2)c1=O
Technical inquiry about: 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
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