3’-O-Benzyl Sofosbuvir Desphosphate
Ref. TR-B289670
250mg
2,087.00€
Product Information
Name:3’-O-Benzyl Sofosbuvir Desphosphate
Controlled Product
Synonyms:
- 1-((2R,3R,4R,5R)-4-(Benzyloxy)-3-fluoro-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Brand:TRC
Description:Applications 3’-O-Benzyl Sofosbuvir Desphosphate may be a metabolite of Sofosbuvir (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:350.35
Formula:C17H19FN2O5
Color/Form:Neat
InChI:InChI=1S/C17H19FN2O5/c1-17(18)14(24-10-11-5-3-2-4-6-11)12(9-21)25-15(17)20-8-7-13(22)19-16(20)23/h2-8,12,14-15,21H,9-10H2,1H3,(H,19,22,23)/t12-,14?,15-,17?/m1/s1
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