Betulin-d3

CAS: 473-98-3

Ref. TR-B330242

Product Information

• Name: Betulin-d3
• Synonyms: Lup-20(29)-ene-3ß,28-diol-d3, Lup-20(30)-ene-3ß,28-diol-d3, 3,28-Dihydroxy-lupeol-d3, 3ß,28-Dihydroxylup-20(29)-ene-d3, Betuline-d3, Betulinic Alcohol-d3, Betulinol-d3, Betulol-d3, NSC 4644-d3, Trochol-d3, (3Beta)-Lup-20(29)-Ene-3,28-Diol, (3Beta,5Xi,9Xi,13Xi,14Xi,18Xi,19Xi)-Lup-20(29)-Ene-3,28-Diol, (3Beta,5Xi,9Xi,18Xi)-Lup-20(29)-Ene-3,28-Diol, (3β)-Lup-20(29)-ene-3,28-diol, 3,28-Dihydroxy-lupeol, 3aH-Cyclopenta[a]chrysene, lup-20(29)-ene-3,28-diol deriv., 3β,28-Dihydroxylup-20(29)-ene, Betuline, Betulinic alcohol, Betulinol, Betulol, Lup-20(29)-Ene-3,28-Diol, Lup-20(29)-en-3,28-diol, (3β)-, Lup-20(29)-ene-3,28-diol, (3β)-, Lup-20(29)-ene-3β,28-diol, Lup-20(30)-ene-3β,28-diol, Lupene-20(29) Diol-3,28, (3Β)-, Nsc 4644, Trochol

Description

Applications Betulin-d3 is the isotope labelled analog of Betulin (B330240); a derivative of Betulinic Acid (B330250) which is a compound used in the treatment of cancer and HIV disease. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity
References Cichewicz, R. et al.: Med. Res. Rev., 24, 90 (2003); Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010)

• Brand: TRC

Chemical properties

• Molecular weight: 445.74
• Formula: C₃₀H₄₇D₃O₂
• Color/Form: Neat
• InChI: InChI=1S/C30H50O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h20-25,31-32H,1,8-18H2,2-7H3/t20-,21+,22?,23+,24-,25+,27?,28?,29?,30+/m0/s1/i12D2,24D
• InChI key: InChIKey=BLQSPZHGZHJLGB-CLFAGFIQSA-N
• SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)OCC(CCl)OC(=O)CCCCCCC/C=C\CCCCCCCC