Betulinic Acid

CAS: 472-15-1

Ref. TR-B330250

Product Information

• Name: Betulinic Acid
• Synonyms: (3β)-3-Hydroxy-lup-20(29)-en-28-oic acid, Lup-20(29)-en-28-oic acid, 3β-hydroxy- (8CI), Mairin (6CI,7CI), 3aH-Cyclopenta[a]chrysene, lup-20(29)-en-28-oic acid deriv., 3β-Hydroxylup-20(29)-en-28-oic acid, Betulic acid, Lupatic acid, NSC 113090, β-Betulinic acid
• Brand: TRC

Description

Applications Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity
References Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010);

Chemical properties

• Molecular weight: 456.7
• Formula: C₃₀H₄₈O₃
• Color/Form: Neat
• InChI: InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1
• InChI key: InChIKey=QGJZLNKBHJESQX-FZFNOLFKSA-N
• SMILES: C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12