(15R)-Bimatoprost Acid-d4

CAS: 41639-71-8

Ref. TR-B386832

Product Information

• Name: (15R)-Bimatoprost Acid-d4
• Synonyms: (Z)-3,3,4,4-tetradeuterio-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoic acid
• CAS: 41639-71-8

Description

Applications (15R)-Bimatoprost Acid-d4 is the isotope labelled analog of (15R)-Bimatoprost Acid (B386830); an impurity of the antiglaucoma agent Bimatoprost (B386820). (15R)-Bimatoprost Acid is a metabolically stable analog of PGF2α (P838625) and is a potent agonist for the FP receptor.
References Balapure, A.K. et al.: Biochem. Pharmacol., 38, 2375 (1989); Hellberg, M.R. et al.: J. Ocular Pharmacol. Ther., 19, 97 (2003); Krishna, P.M. et al.: J. Pharm. res., 4, 2381 (2011); Resul, B., et al.: J. Med. Chem., 36, 243 (1993)

• Brand: TRC

Chemical properties

• Molecular weight: 392.522
• Formula: C₂₃D₄H₂₈O₅
• Color/Form: Neat
• InChI: InChI=1S/C23H32O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-22,24-26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19-,20-,21+,22-/m1/s1/i2D2,7D2
• InChI key: InChIKey=YFHHIZGZVLHBQZ-MNBIYLDLSA-N
• SMILES: [2H]C([2H])(/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@H](O)CCc1ccccc1)C([2H])([2H])CC(=O)O