Product Information
Name:1,3-Bis(2-chloroethyl)urea
Synonyms:
- Urea
- N,N'-bis(2-chloroethyl)-
- Urea
- 1,3-bis(2-chloroethyl)- (6CI,7CI,8CI)
- NSC 36198
Brand:TRC
Description:Stability Hygroscopic, Unstable in SolutionApplications 1,3-Bis(2-chloroethyl)urea is an impurity in the synthesis of Carmustine (C183875), an alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Stahl, et al.: Chem. Res. Toxicol., 5, 106 (1992), Kokkinakis, D.M., et al.: Clin. Cancer Res., 5(11), 3676 (1999), Hickman, M.J., et al.: Proc. Natl. Acad. Sci. USA, 96(19), 10764 (1999),
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Chemical properties
Molecular weight:185.05
Formula:C5H10Cl2N2O
Color/Form:Neat
InChI:InChI=1S/C5H10Cl2N2O/c6-1-3-8-5(10)9-4-2-7/h1-4H2,(H2,8,9,10)
InChI key:InChIKey=VBWBRZHAGLZNST-UHFFFAOYSA-N
SMILES:O=C(NCCCl)NCCCl
Technical inquiry about: 1,3-Bis(2-chloroethyl)urea
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