Product Information
Name:(R)-(+)-Blebbistatin
Controlled Product
Synonyms:
- (3aR)-3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
Brand:TRC
Description:Applications (R)-(+)-Blebbistatin is a 1-phenyl-2-pyrrolidinone derivative and a selective inhibitor of non-muscle myosin II (1, 2, 3). It blocks cell blebbing rapidly and reversibly and also disrupts directed cell migration and cytokinesis in vertebrate cell. (R)-(+)-Blebbistatin can also inhibit contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (R)-(+)-Blebbistatin is suitable as a negative control for (S)-(-)-Blebblastatin.References (1) Straight, A.F., et al.: Science (2003) 299: 1743-7(2) Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun (2004) 313: 992-7 (3) Kovacs, M., et al.: J. Biol. Chem. (2004) 279: 35557-63
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:292.33
Formula:C18H16N2O2
Color/Form:Neat
InChI:InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m0/s1
InChI key:InChIKey=LZAXPYOBKSJSEX-SFHVURJKSA-N
SMILES:Cc1ccc2c(c1)C(=O)[C@@]1(O)CCN(c3ccccc3)C1=N2
Technical inquiry about: (R)-(+)-Blebbistatin
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