(R)-(+)-Blebbistatin

CAS: 1177356-70-5

Ref. TR-B592495

Product Information

• Name: (R)-(+)-Blebbistatin
• Synonyms: (3aR)-3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one

Description

Applications (R)-(+)-Blebbistatin is a 1-phenyl-2-pyrrolidinone derivative and a selective inhibitor of non-muscle myosin II (1, 2, 3). It blocks cell blebbing rapidly and reversibly and also disrupts directed cell migration and cytokinesis in vertebrate cell. (R)-(+)-Blebbistatin can also inhibit contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (R)-(+)-Blebbistatin is suitable as a negative control for (S)-(-)-Blebblastatin.
References (1) Straight, A.F., et al.: Science (2003) 299: 1743-7(2) Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun (2004) 313: 992-7 (3) Kovacs, M., et al.: J. Biol. Chem. (2004) 279: 35557-63

• Brand: TRC

Chemical properties

• Molecular weight: 292.33
• Formula: C₁₈H₁₆N₂O₂
• Color/Form: Neat
• InChI: InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m0/s1
• InChI key: InChIKey=LZAXPYOBKSJSEX-SFHVURJKSA-N
• SMILES: Cc1ccc2c(c1)C(=O)[C@@]1(O)CCN(c3ccccc3)C1=N2