Bodipy Cyclopamine (>85%)

CAS: 334658-24-1

Ref. TR-B674800

Product Information

• Name: Bodipy Cyclopamine (>85%)
• Synonyms: Boron, [5-[(3,5-dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-N-[6-[[2-[(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,2'R,11aS,11bR)-1,2,3,3',3'a,4,5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3-hydroxy-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(4'H)-furo[3,2-b]pyridin]-4'-yl]ethyl]amino]-6-oxohexyl]-1H-pyrrole-2-propanamidato-κN1]difluoro-, (T-4)-, (T-4)-[5-[(3,5-Dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-N-[6-[[2-[(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,2'R,11aS,11bR)-1,2,3,3',3'a,4,5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3-hydroxy-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(4'H)-furo[3,2-b]pyridin]-4'-yl]ethyl]amino]-6-oxohexyl]-1H-pyrrole-2-propanamidato-κN1]difluoroboron, BODIPY-cyclopamine, Bodipy cyclopamine
• Brand: TRC
• Description: Stability Light SensitiveApplications It is a fluorescent derivative of Cyclopamine that retains potency in Shh signaling inhibition (IC50=150nM).References Chen, K.J., et al.: Genes Develop., 16, 2743 (2002)

Chemical properties

• Molecular weight: 841.92
• Formula: C₄₉H₇₀BF₂N₅O₄
• Color/Form: Neat
• InChI: InChI=1S/C49H70BF2N5O4/c1-30-24-44-47(34(5)49(61-44)20-18-39-40-15-11-35-26-38(58)17-19-48(35,6)42(40)28-41(39)33(49)4)55(29-30)23-22-54-45(59)10-8-7-9-21-53-46(60)16-14-36-12-13-37-27-43-31(2)25-32(3)56(43)50(51,52)57(36)37/h11-13,25,27,30,34,38-40,42,44,47,58H,7-10,14-24,26,28-29H2,1-6H3,(H,53,60)(H,54,59)/t30?,34?,38-,39?,40?,42?,44+,47?,48?,49?/m0/s1
• SMILES: CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCCCCC(=O)NCCN3CC(C)C[C@H]4OC5(CCC6C(=C5C)CC5C6CC=C6C[C@@H](O)CCC65C)C(C)C43)n1[B-]2(F)F