(1R,2R)-Bortezomib

CAS: 1132709-15-9

Ref. TR-B675705

Product Information

• Name: (1R,2R)-Bortezomib
• Synonyms: Boronic acid, B-[(1R)-3-methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-, B-[(1R)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid, bortezomib diastereomer (R,R) (USP), bortezomib related compound A (USP)
• Brand: TRC
• Description: Impurity Bortezomib USP Related Compound AApplications (1R,2R)-Bortezomib is a diastereomer of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009)

Chemical properties

• Molecular weight: 384.24
• Formula: C₁₉H₂₅BN₄O₄
• Purity: >85%
• Color/Form: Neat
• InChI: InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17+/m1/s1
• InChI key: InChIKey=GXJABQQUPOEUTA-LDCVWXEPSA-N
• SMILES: CC(C)CC(NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O