Product Information
Name:(+/-)-cis-anti-N2-BPDE-dG-15N5
Controlled Product
Synonyms:
- [7S-(7α,8β,9β,10β)]-2'-Deoxy-N-(7,8,9,10-tetrahydro-7,8,9-trihydroxybenzo[a]pyren-10-yl)guanosine-15N5
- Benzo[a]pyrene Guanosine deriv.-15N5
- (+/-)-cis-anti-7,8,9-Trihydroxy-10-(2'-deoxyguanosin-2-yl)benzo[a]pyrene-15N5
Brand:TRC
Description:Applications (+/-)-cis-anti-N2-BPDE-dG-15N5 is an isotope labelled analog of (-)-trans-anti-N2-BPDE-dG (B676630), which is used in the study of carcinogen-DNA adducts and their role in affecting eukaryotic DNA methyltransferases. Cluster-type DNA damage is often seen in DNA and is usually skipped by base excision repair.References Skosareva, L. et al.: DNA Repair., 11, 367 (2012); Minero, A. et al.: FEBS J. et al.: 279, 3965 (2012); Hoare, S. et al.: Biochem., 39, 12252 (2000); Subach, O. et al.: Biochem., 45, 6142 (2006);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:576.548
Formula:C30H2915N5O7
Color/Form:Neat
InChI:InChI=1S/C30H29N5O7/c36-10-18-17(37)9-19(42-18)35-11-31-24-28(35)33-30(34-29(24)41)32-23-22-15-7-6-13-3-1-2-12-4-5-14(21(15)20(12)13)8-16(22)25(38)27(40)26(23)39/h1,3-4,6-8,11,17-19,23,25-27,36-40H,2,5,9-10H2,(H2,32,33,34,41)/t17-,18+,19+,23+,25+,26+,27-/m0/s1/i31+1,32+1,33+1,34+1,35+1
InChI key:InChIKey=CLQHEFGZYOABQI-VBHAMMDUSA-N
SMILES:O=c1[15nH]c([15NH][C@@H]2c3c(cc4c5c6c(ccc35)C=CCC6=CC4)[C@@H](O)[C@H](O)[C@@H]2O)[15n]c2c1[15n]c[15n]2[C@H]1C[C@H](O)[C@@H](CO)O1
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