tert-Butyl 4-Bromo-2-fluorobenzoate

CAS: 889858-12-2

Ref. TR-B682025

Product Information

• Name: tert-Butyl 4-Bromo-2-fluorobenzoate
• Synonyms: 2-Methylpropan-2-yl 4-bromo-2-fluorobenzoate, 4-Bromo-2-fluoro-benzoic Acid 1,1-Dimethylethyl Ester, 4-Bromo-2-fluoro-benzoic acid tert-butyl ester, Benzoic acid, 4-bromo-2-fluoro-, 1,1-dimethylethyl ester, Tert-Butyl 4-bromo-2-fluorobenzoate, tert-Butyl 2-bromo-4-fluorobenzoate

Description

Applications tert-Butyl 4-Bromo-2-fluorobenzoate is an intermediate of enzalutamide (M199800). Enzalutamide is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.
References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);

• Brand: TRC

Chemical properties

• Molecular weight: 275.11
• Formula: C₁₁H₁₂BrFO₂
• Color/Form: Neat
• InChI: InChI=1S/C11H12BrFO2/c1-11(2,3)15-10(14)8-5-4-7(12)6-9(8)13/h4-6H,1-3H3
• InChI key: InChIKey=ZPGZHSAOCVWZMR-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)c1ccc(Br)cc1F