Bufexamac

CAS: 2438-72-4

Ref. TR-B689390

Product Information

• Name: Bufexamac
• Synonyms: 4-Butoxy-N-hydroxy-benzeneacetamide, 2-(p-Butoxyphenyl)-acetohydroxamic acid, 2-(p-Butoxyphenyl)acetohydroxamic acid, 4-Butoxyphenylacethydroxamic acid, Anderm, Bufexamic acid, CP 1044J3, Droxarol, Droxaryl, Feximac, Flogocid, Flogocid N plasti, Flogocid N plastigel, Malipuran, Mofenar, Norfemac, Parfenac, Parfenal, p-Butoxyphenylacethydroxamic acid, p-Butoxyphenylacetohydroxamic acid, 2-(4-Butoxyphenyl)Acetohydroxamic Acid, 2-(4-butoxyphenyl)-N-hydroxyacetamide, 4-Butoxy-N-hydroxybenzeneacetamide, Acetohydroxamic acid, 2-(p-butoxyphenyl)-, Benzeneacetamide, 4-butoxy-N-hydroxy-, Cp 1044J3, Trolab

Description

Applications Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Bufexamac is a non-steroidal anti-inflammatory drug used topically as well as rectally. Formulations containing Bufexamac is used by many patients with eczematous disorders as an alternative to topical corticosteroids.
References Bantscheff, M. et al.: Nature Biotechnol., 29, 255 (2011); Kranke, B. et al.: Cont. Derm., 36, 212 (1997);

• Brand: TRC

Chemical properties

• Molecular weight: 223.27
• Formula: C₁₂H₁₇NO₃
• Color/Form: White
• InChI: InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)
• InChI key: InChIKey=MXJWRABVEGLYDG-UHFFFAOYSA-N
• SMILES: CCCCOc1ccc(CC(=O)NO)cc1