t-Butyl (3R,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate

CAS: 147489-06-3

Ref. TR-B689830

Product Information

• Name: t-Butyl (3R,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
• Synonyms: 1,3-Dioxane-4-acetic acid, 6-[2-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, [4R-[4α,6α(E)]]-, (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]ethenyl]-2,2-dimethyl-1,3-dioxan-4-ylacetic acid 1,1-dimethylethyl ester
• Brand: TRC
• Description: Applications t-Butyl (3R,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate is an impurity from the synthesis of HMG-CoA reductase inhibitor Pitavastatin [P531040, (Z)-Pitavastatin Calcium Salt].References Takahashi, K., et al.: Tetrahdron Lett., 34, 8263 (1993); Takahashi, K., et al.: Bull. Chem. Soc. Japan, 68, 2649 (1995); Hiyama, T., et al.: Bull. Chem. Soc. Japan, 68, 364 (1995); Manne, S., et al.: Oriental J. Chem., 23, 559 (2007)

Chemical properties

• Molecular weight: 517.631
• Formula: C₃₂H₃₆FNO₄
• Color/Form: Neat
• InChI: InChI=1S/C32H36FNO4/c1-31(2,3)38-28(35)19-24-18-23(36-32(4,5)37-24)16-17-26-29(20-12-14-22(33)15-13-20)25-8-6-7-9-27(25)34-30(26)21-10-11-21/h6-9,12-17,21,23-24H,10-11,18-19H2,1-5H3/b17-16+/t23-,24-/m1/s1