tert-Butyl 6-Chloro-(R)-hydroxy-3-oxohexanoate

CAS: 404958-08-3

Ref. TR-B692820

Product Information

• Name: tert-Butyl 6-Chloro-(R)-hydroxy-3-oxohexanoate
• Synonyms: (5R)-6-Chloro-5-hydroxy-3-oxo-hexanoic Acid 1,1-Dimethylethyl Ester

Description

Applications tert-Butyl 6-Chloro(R)-hydroxy-3-oxohexanoate is a chiral reagent used in the synthesis of callystatin A, a polyketide natural product that functions as an antibiotic. Also an impurity in the synthesis of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006); Enders, D. et al.: Chem. A. Eur. J., 8, 4274 (2002);

• Brand: TRC

Chemical properties

• Molecular weight: 236.69
• Formula: C₁₀H₁₇ClO₄
• Color/Form: Neat
• InChI: InChI=1S/C10H17ClO4/c1-10(2,3)15-9(14)5-7(12)4-8(13)6-11/h8,13H,4-6H2,1-3H3/t8-/m1/s1
• InChI key: InChIKey=WLRFCPQXWBDLRG-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CC(=O)CC(O)CCl