3-(t-Butyldimethylsilyl)morphine N-Oxide

Ref. TR-B807130

Product Information

• Name: 3-(t-Butyldimethylsilyl)morphine N-Oxide
• Synonyms: (3R,4R,4aR,7aR,12bS)-9-((t-Butyldimethylsilyl)oxy)-3-methyl-7-oxo-2,3,4,4a,7,7a-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline 3-Oxide
• Brand: TRC
• Description: Applications 3-(t-Butyldimethylsilyl)morphine N-Oxide is a by-product intermediate in synthesizing Morphinone N-Oxide ()M652352, a derivative of morphinone (M652350), which is a toxic metabolite of Morphine, a controlled substance.References James, R., et al.: J. Pharmacol. Exp. Ther., 221, 708 (1982); Yamano, S., et al.: J. Biol. Chem., 260, 5259 (1985); Ishida, T., et al.: Drug Metab. Dispos., 17, 77 (1989); Yamano, S., et al.: Xenobiotica, 27, 645 (1997)

Chemical properties

• Molecular weight: 415.598
• Formula: C₂₃H₃₃NO₄Si
• Color/Form: Neat
• InChI: InChI=1S/C23H33NO4Si/c1-22(2,3)29(5,6)28-18-10-7-14-13-16-15-8-9-17(25)21-23(15,11-12-24(16,4)26)19(14)20(18)27-21/h7-10,15-17,21,25H,11-13H2,1-6H3/t15-,16+,17-,21-,23-,24?/m0/s1
• InChI key: InChIKey=CBEADXPEORWKDE-ZZNSVWGYSA-N
• SMILES: CC(C)(C)[Si](C)(C)Oc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)[N+](C)([O-])CC[C@]314