tert-Butyl ((S)-4-Methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

CAS: 247068-82-2

Ref. TR-B809210

Product Information

• Name: tert-Butyl ((S)-4-Methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate
• Synonyms: N-[(1S)-3-Methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]carbamic Acid 1,1-Dimethylethyl Ester, [(1S)-3-Methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]carbamic Acid 1,1-Dimethylethyl Ester, (2R)-2-[(2S)-2-(tert-Butoxycarbonylamino)-4-methylpentanoyl]-2-methyloxirane, 1,1-Dimethylethyl N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]carbamate, Boc-L-leucine epoxyketone, Boc-Leucine-epoxylketone, Carbamic acid, N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-dimethylethyl ester, Carbamic acid, [(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-, 1,1-dimethylethyl ester, Carfilzomib intermediate 1, Tert-Butyl 4-Methyl-1-(2-Methyloxiran-2-Yl)-1-Oxopentan-2-Ylcarbamate, Tert-butyl N-[(2s)-4-methyl-1-[(2r)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]carbamate, [3-Methyl-1-(2-methyl-oxiranecarbonyl)-butyl]-carbamic acid tert-butyl ester, tert-butyl (S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylcarbamate

Description

Applications tert-Butyl ((S)-4-Methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Wang, P., et al.: Process for preparation of carfilzomib, China Patent 2015010436, Jan 29, 2015; Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012)

• Brand: TRC

Chemical properties

• Molecular weight: 271.35
• Formula: C₁₄H₂₅NO₄
• Color/Form: Neat
• InChI: InChI=1S/C14H25NO4/c1-9(2)7-10(11(16)14(6)8-18-14)15-12(17)19-13(3,4)5/h9-10H,7-8H2,1-6H3,(H,15,17)/t10?,14-/m1/s1
• InChI key: InChIKey=DDMPMIMTLBGEHT-LNUXAPHWSA-N
• SMILES: CC(C)CC(NC(=O)OC(C)(C)C)C(=O)[C@@]1(C)CO1