t-Butyldimethylsilyl Tylosin

Ref. TR-B942875

Product Information

• Name: t-Butyldimethylsilyl Tylosin
• Synonyms: 2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-15-[[(2R,3R,4S,5R,6R)-5-[tert-butyl(dimethyl)silyl]oxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde
• Brand: TRC
• Description: Applications t-Butyldimethylsilyl Tylosin is an intermediate used in the synthesis of Tylosin-d3 (T947652), which is labelled Tylosin (T947650). Tylosin is a macrolide antibiotic isolated from a strain of Streptomycetes fradiae found in soil from Thailand. Antibacterial.References Hamill, et al.: Antibiot. Chemother., 11, 328 (1961), Corcoran, J.W., et al.: J. Antibiot., 30, 1012 (1977), Seno, E.T., et al.: Antimicrob. Agents. Chemother., 11, 455 (1977),

Chemical properties

• Molecular weight: 1030.361
• Formula: C₅₂H₉₁NO₁₇Si
• Color/Form: Neat
• InChI: InChI=1S/C52H91NO17Si/c1-18-38-35(27-63-50-47(62-15)46(61-14)45(32(6)66-50)70-71(16,17)51(8,9)10)23-28(2)19-20-36(55)29(3)24-34(21-22-54)43(30(4)37(56)25-39(57)67-38)69-49-42(58)41(53(12)13)44(31(5)65-49)68-40-26-52(11,60)48(59)33(7)64-40/h19-20,22-23,29-35,37-38,40-50,56,58-60H,18,21,24-27H2,1-17H3/b20-19+,28-23+/t29-,30+,31-,32-,33+,34+,35-,37-,38-,40+,41-,42-,43-,44-,45-,46-,47-,48+,49+,50-,52-/m1/s1
• InChI key: InChIKey=MWLOMMCRCQYUGF-XZAWMORCSA-N
• SMILES: CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](OC)[C@H]1OC