Estimated delivery in United States, on Thursday 19 Dec 2024
Product Information
Name:
Cabozantinib (Phenylene-d4) L-Malate Salt
Controlled Product
Synonyms:
- N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide-d4 (2S)-2-Hydroxybutanedioic Acid
- Cabozantini-d4 S-Malate
- XL 184-d4
- (2S)-2-Hydroxybutanedioic acid compd.with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide(1:1)
- (2S)-2-hydroxybutanedioic acid
- Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4- quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
- Cabozantinib L-(-)-Apple Acid
- Cabozantinib L-Malate
- Cabozantinib Malate
- Cometriq
- See more synonyms
- N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide mono[(2S)-2-hydroxybutanedioate]
- N1-[4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N1'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
- Xl 184
Description:
Applications Cabozantinib-d4 L-Malate Salt, is the labeled analogue of Cabozantinib L-Malate Salt (C051500), which is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and has been shown to reduce tumor growth, metastasis, and angiogenesis.
References Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010),
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
639.62
Formula:
C28D4H20FN3O5·C4H6O5
Color/Form:
Neat
InChI:
InChI=1S/C28H24FN3O5.C4H6O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;5-2(4(8)9)1-3(6)7/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);2,5H,1H2,(H,6,7)(H,8,9)/t;2-/m.0/s1/i7D,8D,9D,10D;
InChI key:
InChIKey=HFCFMRYTXDINDK-AWVSFGHMSA-N
SMILES:
O=C(O)C[C@H](O)C(=O)O.[2H]c1c([2H])c(Oc2ccnc3cc(OC)c(OC)cc23)c([2H])c([2H])c1NC(=O)C1(C(=O)Nc2ccc(F)cc2)CC1
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Technical inquiry about: TR-C051502 Cabozantinib (Phenylene-d4) L-Malate Salt
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