Product Information
Name:Cabozantinib Hydrogen Sulfate
Controlled Product
Synonyms:
- 1,1-Cyclopropanedicarboxamide
- N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N′-[4-fluoro-2-(sulfooxy)phenyl]- (ACI)
- N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N′-[4-fluoro-2-(sulfooxy)phenyl]-1,1-cyclopropanedicarboxamide (ACI)
Brand:TRC
Description:
Applications Cabozantinib Hydrogen Sulfate is a metabolite of cabozantinib(C051500). Cabozantinib is a small molecule C-Met modulator. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.
References Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010); Wu, C., et al.: J. Pharm. Biomed. Anal., 98, 356 (2014)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:597.568
Formula:C28H24FN3O9S
Color/Form:Neat
InChI:InChI=1S/C28H24FN3O9S/c1-38-24-14-19-21(15-25(24)39-2)30-12-9-22(19)40-18-6-4-17(5-7-18)31-26(33)28(10-11-28)27(34)32-20-8-3-16(29)13-23(20)41-42(35,36)37/h3-9,12-15H,10-11H2,1-2H3,(H,31,33)(H,32,34)(H,35,36,37)
InChI key:InChIKey=VFXIPUKNLGLBNJ-UHFFFAOYSA-N
SMILES:COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5OS(=O)(=O)O)CC4)cc3)c2cc1OC
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