9-(2-Carboxyphenyl)-2,7-dimethyl-3,6-bis(ethylamino)xanthylium

CAS: 25152-49-2

Ref. TR-C178520

Product Information

• Name: 9-(2-Carboxyphenyl)-2,7-dimethyl-3,6-bis(ethylamino)xanthylium
• Synonyms: Rhodamine 19, Rhodamine 19 Zwitterion, Rhodamine 575, o-[6-(Ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xanthen-9-yl]-benzoic Acid, 9-(2-Carboxyphenyl)-3,6-bis(ethylamino)-2,7-dimethylxanthylium Inner Salt

Description

Applications 9-(2-Carboxyphenyl)-2,7-dimethyl-3,6-bis(ethylamino)xanthylium is an intermediate in the synthesis of SkQR1 (S555050), a mitochondria-targeted plastoquinone antioxidant that exhibits neuroprotective effect. Potent Mitochondrial Targeted antioxidant protecting against the anti-cancer treatment related to oxidative stress (1). Depicted positive effects on rat memory. (2)SkQRl is the substrate of multidrug resistance pump P-glycoproten (Pgp 170) and selectively protects Pgp 170-negative cells against oxidative stress (3)
References Fetisova EK, et al. 2010. FEBS Lett. Feb 5;584(3):562-6Stelmashook EV, 2015. Biochemistry (Mosc). May;80(5):592-5 Fetisova EK, et al. 2015. Radiat Res. Jan;183(1):64-71

• Brand: TRC

Chemical properties

• Molecular weight: 414.5
• Formula: C₂₆H₂₆N₂O₃
• Color/Form: Neat
• InChI: InChI=1S/C26H26N2O3/c1-5-27-21-13-23-19(11-15(21)3)25(17-9-7-8-10-18(17)26(29)30)20-12-16(4)22(28-6-2)14-24(20)31-23/h7-14,27-28H,5-6H2,1-4H3