N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine

CAS: 1384516-10-2

Ref. TR-C364235

Product Information

• Name: N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine
• Synonyms: N-[(4-Chlorophenyl)methyl]-5-nitro-2-thiophenemethanamine (ACI)
• Brand: TRC
• Description: Applications N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine is an analogue of GSK 4112 (G797700) which is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.References Kojetin, D. et al.: ACS Chem. Biol., 6, 131 (2011); Grant, D. et al.: ACS Chem. Biol., 5, 925 (2010)

Chemical properties

• Molecular weight: 282.746
• Formula: C₁₂H₁₁ClN₂O₂S
• Color/Form: Neat
• InChI: InChI=1S/C12H11ClN2O2S/c13-10-3-1-9(2-4-10)7-14-8-11-5-6-12(18-11)15(16)17/h1-6,14H,7-8H2
• SMILES: O=[N+]([O-])c1ccc(CNCc2ccc(Cl)cc2)s1