N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine
CAS: 1384516-10-2
Ref. TR-C364235
| 50mg | 245.00 € | ||
| 500mg | 1,638.00 € |
Product Information
- N-[(4-Chlorophenyl)methyl]-5-nitro-2-thiophenemethanamine (ACI)
Applications N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine is an analogue of GSK 4112 (G797700) which is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.
References Kojetin, D. et al.: ACS Chem. Biol., 6, 131 (2011); Grant, D. et al.: ACS Chem. Biol., 5, 925 (2010)
Chemical properties
Technical inquiry about: TR-C364235 N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine
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