(S)-2-Chloro-1-(3,4-difluorophenyl)ethanol

CAS: 1006376-60-8

Ref. TR-C365268

Product Information

• Name: (S)-2-Chloro-1-(3,4-difluorophenyl)ethanol
• Synonyms: (aS)-a-(Chloromethyl)-3,4-difluorobenzenemethanol, (1S)-2-Chloro-1-(3,4-difluorophenyl)ethan-1-ol, (1S)-2-Chloro-1-(3,4-difluorophenyl)ethanol, (αS)-α-(Chloromethyl)-3,4-difluorobenzenemethanol, Benzenemethanol, α-(chloromethyl)-3,4-difluoro-, (αS)-

Description

Applications (S)-2-Chloro-1-(3,4-difluorophenyl)ethanol is a building block used in organic synthesis including bein an intermediate in the synthesis of Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel.
References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),

• Brand: TRC

Chemical properties

• Molecular weight: 192.59
• Formula: C₈H₇ClF₂O
• Color/Form: Neat
• InChI: InChI=1S/C18H12Cl12/c19-9-10(20)15(25)7-3-4-8-6(2-1-5(7)13(9,23)17(15,27)28)14(24)11(21)12(22)16(8,26)18(14,29)30/h5-8H,1-4H2/t5-,6+,7+,8-,13-,14+,15+,16?/m1/s1
• InChI key: InChIKey=UGQQAJOWXNCOPY-BKPFTMJTSA-N
• SMILES: ClC1=C(Cl)[C@]2(Cl)[C@@H]3CC[C@H]4[C@@H](CC[C@@H]3[C@@]1(Cl)C2(Cl)Cl)[C@@]1(Cl)C(Cl)=C(Cl)[C@]4(Cl)C1(Cl)Cl