(Z)-Chlorolefin-13C6

CAS: 97818-83-2

Ref. TR-C365781

Product Information

• Name: (Z)-Chlorolefin-13C6
• Synonyms: (Z)-1-[4-(2-Chloroethoxyphenyl]-1,2-diphenyl-1-butene-13C6

Description

Applications (Z)-Chlorolefin-13C6 is an intermediate in the synthesis of Tamoxifen-13C6 (T006002), which is a labeled Tamoxifen; a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen (H954725) are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-sti
References Sutherland, R., et al.: Nature, 267, 434 (1977); Lerner, L., et al.: Cancer Res., 50, 4177 (1990); Love, R., et al.: J. Clin. Oncol., 20 2559 (2002);

• Brand: TRC

Chemical properties

• Molecular weight: 368.848
• Formula: C₆C₁₈H₂₃ClO
• Color/Form: Neat
• InChI: InChI=1S/C24H23ClO/c1-2-23(19-9-5-3-6-10-19)24(20-11-7-4-8-12-20)21-13-15-22(16-14-21)26-18-17-25/h3-16H,2,17-18H2,1H3/b24-23-/i4+1,7+1,8+1,11+1,12+1,20+1
• InChI key: InChIKey=GWAJMDNEUFHRBV-HKIUWNKUSA-N
• SMILES: CC/C(=C(/c1ccc(OCCCl)cc1)[13c]1[13cH][13cH][13cH][13cH][13cH]1)c1ccccc1