Product Information
Name:(Z)-Chlorolefin-13C6
Controlled Product
Synonyms:
- (Z)-1-[4-(2-Chloroethoxyphenyl]-1,2-diphenyl-1-butene-13C6
Brand:TRC
Description:Applications (Z)-Chlorolefin-13C6 is an intermediate in the synthesis of Tamoxifen-13C6 (T006002), which is a labeled Tamoxifen; a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen (H954725) are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stiReferences Sutherland, R., et al.: Nature, 267, 434 (1977); Lerner, L., et al.: Cancer Res., 50, 4177 (1990); Love, R., et al.: J. Clin. Oncol., 20 2559 (2002);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:368.848
Formula:C6C18H23ClO
Color/Form:Neat
InChI:InChI=1S/C24H23ClO/c1-2-23(19-9-5-3-6-10-19)24(20-11-7-4-8-12-20)21-13-15-22(16-14-21)26-18-17-25/h3-16H,2,17-18H2,1H3/b24-23-/i4+1,7+1,8+1,11+1,12+1,20+1
InChI key:InChIKey=GWAJMDNEUFHRBV-HKIUWNKUSA-N
SMILES:CC/C(=C(/c1ccc(OCCCl)cc1)[13c]1[13cH][13cH][13cH][13cH][13cH]1)c1ccccc1
Technical inquiry about: (Z)-Chlorolefin-13C6
Please use instead the cart to request a quotation or an order
If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.