4-Chloro Kynurenine

CAS: 75802-84-5

Ref. TR-C366940

Product Information

• Name: 4-Chloro Kynurenine
• Synonyms: a,2-Diamino-4-chloro-?-oxobenzenebutanoic Acid, (+/-)-a,2-Diamino-4-chloro-?-oxobenzenebutanoic Acid, 4-Cl-KYN, (+/-)-AV-101

Description

Applications 7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.
References Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994), Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (2001), Palmer, G., et al.: Curr. Drug Targets, 2, 241 (2001), Wu, H., et al.: Exp. Neurol., 177, 222 (2002),

• Brand: TRC

Chemical properties

• Molecular weight: 242.66
• Formula: C₁₀H₁₁ClN₂O₃
• Color/Form: Neat
• InChI: InChI=1S/C10H11ClN2O3/c11-5-1-2-6(7(12)3-5)9(14)4-8(13)10(15)16/h1-3,8H,4,12-13H2,(H,15,16)
• InChI key: InChIKey=HQLHZNDJQSRKDT-UHFFFAOYSA-N
• SMILES: Nc1cc(Cl)ccc1C(=O)CC(N)C(=O)O