Product Information
Name:4-Chloro-3-fluoroaniline
Controlled Product
Synonyms:
- 4-Chloro-3-fluoro-aniline
- 3-Fluoro-4-chloroaniline
- 3-Fluoro-4-chlorobenzenamine
- 4-Chloro-3-fluorobenzenamine
- 4-Chloro-3-fluoro-benzeneamine
- 4-Chloro-3-fluorophenylamine
Brand:TRC
Description:Applications 4-Chloro-3-fluoroaniline is used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate; a key intermediate towards phosphoindole inhibitors of HIV non-nucleoside reverse transcriptase. 4-Chloro-3-fluoroaniline is also used in the synthesis of 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib (D289540) which is an impurity of the tyrosine kinase inhibitor Gefitinib (G304000). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Mayes, B.A., et al.: Org. Process Res. Dev., 14, 1248 (2010); Lynch, T.J., et al.: N. Engl. J. Med., 350, 2129 (2004); Engelman, J.A., et al.: Science, 316, 1039 (2007); Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:145.56
Formula:C6H5ClFN
Color/Form:Neat
InChI:InChI=1S/C6H5ClFN/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2
InChI key:InChIKey=ACMJJQYSPUPMPN-UHFFFAOYSA-N
SMILES:Nc1ccc(Cl)c(F)c1
Technical inquiry about: 4-Chloro-3-fluoroaniline
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