(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
CAS:
Ref. TR-C367720
1g
353.00€
100mg
180.00€
500mg
259.00€
Product Information
Name:(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
Controlled Product
Synonyms:
- Afatinib Impurity 47
Brand:TRC
Description:Applications (S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib (A355305) which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.References Zhang, X., et al.: Bioorg. Med. Chem., 21, 7988 (2013); Ermoli, A. et al.: J. Med. Chem., 52, 4380 (2009); Pearson, S. et al.: Synthesis, 15, 2503 (2005);
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Chemical properties
Molecular weight:404.78
Formula:C18H14ClFN4O4
Color/Form:Neat
InChI:InChI=1S/C18H14ClFN4O4/c19-13-5-10(1-2-14(13)20)23-18-12-6-16(24(25)26)17(7-15(12)21-9-22-18)28-11-3-4-27-8-11/h1-2,5-7,9,11H,3-4,8H2,(H,21,22,23)
Technical inquiry about: (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
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