N-[[4-[2-[(5-Chloro-2-methoxybenzoyl)amino]ethyl]phenyl]sulfonyl]carbamic Acid Methyl Ester

CAS: 21165-77-5

Ref. TR-C367875

Product Information

• Name: N-[[4-[2-[(5-Chloro-2-methoxybenzoyl)amino]ethyl]phenyl]sulfonyl]carbamic Acid Methyl Ester
• Synonyms: Methyl [[4-[2-[(5-Chloro-2-methoxybenzoyl)amino]ethyl]phenyl]sulphonyl]carbamate, Glibenclamide Imp. B (EP)
• Brand: TRC

Description

Applications N-[[4-[2-[(5-Chloro-2-methoxybenzoyl)amino]ethyl]phenyl]sulfonyl]carbamic Acid Methyl Ester is an impurity in the synthesis of Gyburide (G598350), a second generation sulfonylurea with hypoglycemic activity. Glyburide is an antidiabetic.
References Mizukami, et al.: Arzneimittel-Forsch., 19, 1413 (1969); Efendic, S., et al.: Proc. Nat. Acad. Sci. USA, 76, 5901 (1979); Feldman, J.M.: Pharmacotherapry, 5, 43 (1985);

Chemical properties

• Molecular weight: 426.87
• Formula: C₁₈H₁₉ClN₂O₆S
• Color/Form: Neat
• InChI: InChI=1S/C18H19ClN2O6S/c1-26-16-8-5-13(19)11-15(16)17(22)20-10-9-12-3-6-14(7-4-12)28(24,25)21-18(23)27-2/h3-8,11H,9-10H2,1-2H3,(H,20,22)(H,21,23)
• InChI key: InChIKey=FHUMMCKSSXULQH-UHFFFAOYSA-N
• SMILES: COC(=O)NS(=O)(=O)c1ccc(CCNC(=O)c2cc(Cl)ccc2OC)cc1