2-Chloro-6-methoxy-4-methylquinoline

CAS: 6340-55-2

Ref. TR-C370060

Product Information

• Name: 2-Chloro-6-methoxy-4-methylquinoline
• Synonyms: 2-Chloro-4-methyl-6-methoxyquinoline, NSC 13577, NSC 51245, 2-hloro-6-methoxy-lepidine

Description

Applications 2-Chloro-6-methoxy-4-methylquinoline is an intermediate in the synthesis of Tafenoquine-d3 Succinate which is the labelled analog of Tatenoquine (T004760), a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.
References McIntyre, J. A., et al.: Drugs. Future., 28, 859 (2003); LaMontagne, M.P., et al.: J. Medn. Chem., 32, 1728 (1989);

• Brand: TRC

Chemical properties

• Molecular weight: 207.66
• Formula: C₁₁H₁₀ClNO
• Color/Form: Neat
• InChI: InChI=1S/C27H40N2O7.ClH/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32;/h14-15,17-18,21-22,28H,5-13,16H2,1-4H3,(H,31,32);1H/t17-,21+,22-;/m0./s1
• InChI key: InChIKey=UTHZRYWNZSWSDS-RDZNBAMBSA-N
• SMILES: CCOC(=O)[C@@H](CCC1CCCCC1)N[C@@H](C)C(=O)N1Cc2cc(OC)c(OC)cc2C[C@H]1C(=O)O.Cl