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2-Chloro-5-nitro-N-4-pyridinylbenzamide
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2-Chloro-5-nitro-N-4-pyridinylbenzamide

CAS: 313516-66-4

Ref. TR-C374760

5mg
94.00 €
10mg
119.00 €
Estimated delivery in United States, on Tuesday 10 Dec 2024

Product Information

Name:
2-Chloro-5-nitro-N-4-pyridinylbenzamide
Controlled Product
Synonyms:
  • 2-chloro-5-nitro-N-pyridin-4-ylbenzamide
  • Benzamide, 2-chloro-5-nitro-N-4-pyridinyl-
  • T-0070907
  • T0070907
Description:

Applications A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 µM and 1.8 µM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.
References Lee, G., et al: J. Biol. Chem., 277, 19649 (2003), Schaefer, K.L., et al: Cancer Res., 65, 2251 (2005), Masuda, T., et al.: Clin. Cancer Res., 11, 4012 (2005), Raikwar, H.P., et al.: J. Neuroimmunol., 167, 99 (2005)

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:

Chemical properties

Molecular weight:
277.66
Formula:
C12H8ClN3O3
Color/Form:
Neat
InChI:
InChI=1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)
SMILES:
O=C(Nc1ccncc1)c1cc([N+](=O)[O-])ccc1Cl
MDL:
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Hazard Info

UN Number:
EQ:
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Forbidden to fly:
Hazard Info:
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LQ:

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