3-(3-Chloropropyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one-d6

CAS: 85175-65-1

Ref. TR-C375262

Product Information

• Name: 3-(3-Chloropropyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one-d6
• Synonyms: 3-(3-chloro-1,1,2,2,3,3-hexadeuteriopropyl)-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one

Description

Applications 3-(3-Chloropropyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one is an impurity in the synthesis of Ivabradine (I940500), a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal.
References Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994), Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998), Borer, J.S., et al.: Circulation, 107, 817 (2003), DiFrancesco, D., et al.: Drugs, 64, 1757 (2004),

• Brand: TRC

Chemical properties

• Molecular weight: 303.814
• Formula: C₁₅D₆H₁₄ClNO₃
• Color/Form: Neat
• InChI: InChI=1S/C15H20ClNO3/c1-19-13-8-11-4-7-17(6-3-5-16)15(18)10-12(11)9-14(13)20-2/h8-9H,3-7,10H2,1-2H3/i3D2,5D2,6D2
• InChI key: InChIKey=UKLLLQWDPVQNPO-GBEYRIOTSA-N
• SMILES: [2H]C([2H])(Cl)C([2H])([2H])C([2H])([2H])N1CCc2cc(OC)c(OC)cc2CC1=O