5-Chloro-4-(3-pyridinyl)-2-pyrimidinamine
CAS:
Ref. TR-C376016
100mg
374.00€
250mg
850.00€
500mg
1,648.00€
Product Information
Name:5-Chloro-4-(3-pyridinyl)-2-pyrimidinamine
Controlled Product
Synonyms:
- 5-chloro-4-pyridin-3-ylpyrimidin-2-amine
Brand:TRC
Description:Applications 5-Chloro-4-(3-pyridinyl)-2-pyrimidinamine is an intermediate in the synthesis of 3-((5-Chloro-4-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide (C179120), an impurity of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),
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Chemical properties
Molecular weight:206.63
Formula:C9H7ClN4
Color/Form:Neat
InChI:InChI=1S/C9H7ClN4/c10-7-5-13-9(11)14-8(7)6-2-1-3-12-4-6/h1-5H,(H2,11,13,14)
InChI key:InChIKey=WSIXNFZXJAABLD-UHFFFAOYSA-N
SMILES:Nc1ncc(Cl)c(-c2cccnc2)n1
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