1-(3-Chlorophenyl)piperazine-d8

CAS: 1189923-43-0

Ref. TR-C379592

Product Information

• Name: 1-(3-Chlorophenyl)piperazine-d8
• Synonyms: 1-(m-Chlorophenyl)piperazine-d8, 4-(3-Chlorophenyl)piperazine-d8, N-(3-Chlorophenyl)piperazine-d8, N-(m-Chlorophenyl)piperazine-d8, NSC 49307-d8, mCPP-d8
• Brand: TRC
• Description: Applications It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone. The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone.References Melzacka, M., et al.: Pol. J. Pharmacol Pharm., 32, 551 (1980), Fong, M.H., et al.: J. Pharm. Pharmacol., 34, 674 (1982), Fiorella, D., et al.: Psychopharmacology, 119, 220 (1995), Maes, M., et al.: J. Clin. Psychopharmacol., 17, 358 (1997), Bo Wen, et al.: Drug Metab. Dispos., 36, 841 (2008),

Chemical properties

• Molecular weight: 204.73
• Formula: C₁₀H₅D₈ClN₂
• Color/Form: Neat
• InChI: InChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2/i4D2,5D2,6D2,7D2
• InChI key: InChIKey=VHFVKMTVMIZMIK-DUSUNJSHSA-N
• SMILES: [2H]C1([2H])NC([2H])([2H])C([2H])([2H])N(c2cccc(Cl)c2)C1([2H])[2H]