(S)-2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine

CAS: 201594-84-5

Ref. TR-C380335

Product Information

• Name: (S)-2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine
• Synonyms: 2-[(S)-(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine, 2-[(S)-(4-Chlorophenyl)-(4-piperidinyloxy)-methyl]-pyridine, 2-[(S)-(4-chlorophenyl)(piperidin-4-yloxy)methyl]pyridine, (S)-4-[1-(4-Chlorophenyl)-1-(2-pyridyl) methoxy] piperidine (for Bepotastine), (S)-4-[1-(4-Chlorophenyl)-1-(2-pyridyl) methoxy] piperidine, Bepotastine Intermediate-1, (S)-2-((4-chlorophenyl)(piperidin-4-yloxy)methyl)pyridine

Description

Applications (S)-2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine is used as a reagent to prepare optically active 4-[(4-chlorophenyl-2-pyridyl)methoxy]piperidine, a compound that is used as an intermediate in the synthesis of antihistamines and antiallergy agents. (S)-2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine is also an intermediate of Bepotastine besylate (B317000), a non-sedating H1-antagonist that has anti-inflammatory activity.
References Kita, J. Preparation of Optically Active 4-[(4-Chlorophenyl-2-pyridyl)methoxy]piperidine As A Material For Antihistamines and Antiallergy Agents. Jpn. Kokai Tokkyo Koho JP 10182635. Jul 7, 1998; Ohashi, R., et al.: Drug Metab. Disp., 34, 793 (2006)

• Brand: TRC

Chemical properties

• Molecular weight: 302.8
• Formula: C₁₇H₁₉ClN₂O
• Color/Form: Neat
• InChI: InChI=1S/C17H19ClN2O/c18-14-6-4-13(5-7-14)17(16-3-1-2-10-20-16)21-15-8-11-19-12-9-15/h1-7,10,15,17,19H,8-9,11-12H2/t17-/m0/s1
• InChI key: InChIKey=OTZYADIPHOGUDN-KRWDZBQOSA-N
• SMILES: Clc1ccc([C@H](OC2CCNCC2)c2ccccn2)cc1