Cidofovir Hydrate

CAS: 113852-37-2

Ref. TR-C433500

Product Information

• Name: Cidofovir Hydrate
• Synonyms: Cidofovir, P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, (S)-HPMPC, GS-504, Vistide, (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine, (S)-Hpmpc, ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid, 1-(S)-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine, 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine, Cidofovir (anhydrous), Cidofovir monophosphate, Cidovir, Gs 0504, Hpmpc, Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, (S)-, Phosphonic acid, P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-, Phosphonic acid, [[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-, Unii-768M1V522C, {[2-(4-amino-2-oxopyrimidin-1(2H)-yl)-1-(hydroxymethyl)ethoxy]methyl}phosphonic acid

Description

Applications An injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is used in the treatment of acyclovir resistant herpes as well as a complementary intralesional therapy against papillomatosis caused by human papillomavirus (HPV).
References Rahal, F.M. et al.: Ann. Internal Med., 125, 98 (1996); Johnson, J.A. et al.: Antimicrob. Agents Chemother., 43, 1190 (1999); Ho, H.T. et al.: Mol. Pharmacol., 41, 197 (1992);

• Brand: TRC

Chemical properties

• Molecular weight: 279.19
• Formula: C₈H₁₄N₃O₆P
• Color/Form: White Powder
• InChI: InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
• SMILES: N=c1ccn(C[C@@H](CO)OCP(=O)([O-])O)c([O-])n1.[Na+].[Na+]