N-(4-Chloro-2-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine
CAS:
Ref. TR-C472235
5mg
290.00€
10mg
515.00€
25mg
1,203.00€
Product Information
Name:N-(4-Chloro-2-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine
Controlled Product
Synonyms:
- (4-Chloro-pyrimidin-2-yl)-(2,3-dimethyl-2H-indazol-6-yl)-methyl-amine
Brand:TRC
Description:Applications N-(4-Chloro-2-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an intermediate in the synthesis of 5-((2-((2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-4-yl)amino)-2-methylbenzenesulfonamide Hydrochloride (D474433) which is an impurity of Pazopanib (P210925), which is an oral angiogenesis inhibitor targeting VEGFR and PDGFR.References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),
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Chemical properties
Molecular weight:287.75
Formula:C14H14ClN5
Color/Form:Neat
InChI:InChI=1S/C14H14ClN5/c1-9-11-5-4-10(8-12(11)18-20(9)3)19(2)14-16-7-6-13(15)17-14/h4-8H,1-3H3
InChI key:InChIKey=JYPPKOMRVIEEAF-UHFFFAOYSA-N
SMILES:Cc1c2ccc(N(C)c3nccc(Cl)n3)cc2nn1C
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