Product Information
Name:CK 1827452
Controlled Product
Synonyms:
- 1-Piperazinecarboxylic acid
- 4-[[2-fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-
- methyl ester (9CI
- ACI)
- Methyl 4-[[2-fluoro-3-[N'-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate
- Omecamtiv mecarbil
Brand:TRC
Description:Applications CK 1827452 is a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452 increases cardiac function by increasing the duration of ejection without changing the rates of contraction.References Meijs, M. et al.: Eur. J. Heart. Fail., 14, 232 (2012); Malik, F. et al.: J. Mol. Cell. Card., 51, 454 (2011)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:401.43
Formula:C20H24FN5O3
Color/Form:Neat
InChI:InChI=1S/C20H24FN5O3/c1-14-6-7-16(12-22-14)23-19(27)24-17-5-3-4-15(18(17)21)13-25-8-10-26(11-9-25)20(28)29-2/h3-7,12H,8-11,13H2,1-2H3,(H2,23,24,27)
InChI key:InChIKey=RFUBTTPMWSKEIW-UHFFFAOYSA-N
SMILES:COC(=O)N1CCN(Cc2cccc(NC(=O)Nc3ccc(C)nc3)c2F)CC1
Technical inquiry about: CK 1827452
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