CK 1827452-d8

CAS: 873697-71-3

Ref. TR-C544002

Product Information

• Name: CK 1827452-d8
• Synonyms: 4-[[2-Fluoro-3-[[[(6-methyl-3-pyridinyl-d8)amino]carbonyl]amino]phenyl]methyl]-1-piperazinecarboxylic Acid Methyl Ester, Omecamtiv Mecarbil, Methyl 4-[[2-Fluoro-3-[N'-(6-methylpyridin-3-yl-d8)ureido]phenyl]methyl]piperazine-1-carboxylate, 4-[[2-Fluoro-3-[[[(6-methyl-3-pyridinyl-d8)amino]carbonyl]amino]phenyl]methyl]-1-piperazinecarboxylic Acid Methyl Ester, Ck-1827452, Methyl 4-[[2-fluoro-3-[N′-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate, Omecamtiv mecarbil, 1-Piperazinecarboxylic acid, 4-[[2-fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-, methyl ester

Description

Applications CK 1827452-d8 is the labeled analogue of CK 1827452 (C544000), a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452 increases cardiac function by increasing the duration of ejection without changing the rates of contraction.
References Meijs, M. et al.: Eur. J. Heart. Fail., 14, 232 (2012); Malik, F. et al.: J. Mol. Cell. Card., 51, 454 (2011)

• Brand: TRC

Chemical properties

• Molecular weight: 409.48
• Formula: C₂₀H₁₆D₈FN₅O₃
• Color/Form: Beige
• InChI: InChI=1S/C20H24FN5O3/c1-14-6-7-16(12-22-14)23-19(27)24-17-5-3-4-15(18(17)21)13-25-8-10-26(11-9-25)20(28)29-2/h3-7,12H,8-11,13H2,1-2H3,(H2,23,24,27)/i8D2,9D2,10D2,11D2
• InChI key: InChIKey=RFUBTTPMWSKEIW-JNJBWJDISA-N
• SMILES: [2H]C1([2H])N(Cc2cccc(NC(=O)Nc3ccc(C)nc3)c2F)C([2H])([2H])C([2H])([2H])N(C(=O)OC)C1([2H])[2H]