Clemizole Hydrochloride

CAS: 1163-36-6

Ref. TR-C559740

Product Information

• Name: Clemizole Hydrochloride
• Synonyms: 1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:1), 1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-, monohydrochloride (9CI), Benzimidazole, 1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-, monohydrochloride (8CI), 1-(4-Chlorobenzyl)-2-(pyrrolidinylmethyl)-1,3-benzimidazole hydrochloride, 1-p-Chlorobenzyl-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride, 1-p-Chlorobenzyl-2-pyrrolidylmethyl benzimidazole hydrochloride, AL 20, Allercur, Histacuran, Klemidox, Reactrol, 1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole hydrochloride, 1-[4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole, Monohydrochloride, 1-{[1-(4-chlorobenzyl)-1H-benzimidazol-2-yl]methyl}pyrrolidinium chloride, 1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:1), 1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-, monohydrochloride, Al 20, Benzimidazole, 1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-, monohydrochloride

Description

Applications Clemizole Hydrochloride inhibits Hepatitis C RNA replication in cell culture through the suppression of the binding between the nonstructural protein 4B and the viral RNA genome with little toxicity for the host cell. Clemizole Hydrochloride is also a potent inhibitor of transient receptor potential channel TRPC5.
References Einav, S., et al.: Nat. Biotechnol., 26, 1019 (2008); Richter, J. M., et al.: Mol. Pharmacol., 86, 514 (2014)

• Brand: TRC

Chemical properties

• Molecular weight: 362.30
• Formula: C₁₉H₂₀ClN₃·ClH
• Color/Form: Neat
• InChI: InChI=1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H
• InChI key: InChIKey=DNFMJYXRIMLMBZ-UHFFFAOYSA-N
• SMILES: Cl.Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1