Product Information
Name:Clasto-lactacystin(Omuralide)
Controlled Product
Synonyms:
- (1R,4R,5S)-1-[(1S)-1-Hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
- Clasto-lactacystin beta-Lactone
- Omuralide
Brand:TRC
Description:Applications A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.References Craiu, A., et al.: J. Biol. Chem., 272, 13437 (1997), Dick, G.L.R., et al.: J. Biol. Chem., 272, 182 (1997), Fenteany, G. and Schreiber, S.: J. Biol. Chem., 273, 8545 (1998), Corey, E.J., et al.: J.A.C.S., 120, 2330 (1998)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:213.23
Formula:C10H15NO4
Color/Form:Neat
InChI:InChI=1S/C10H15NO4/c1-4(2)7-10(9(14)15-7)6(12)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10+/m1/s1
InChI key:InChIKey=FWPWHHUJACGNMZ-NUMRIWBASA-N
SMILES:CC(C)[C@H](O)[C@]12N=C(O)[C@H](C)[C@@H]1OC2=O
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