Clotiazepam

CAS: 33671-46-4

Ref. TR-C587410

Product Information

• Name: Clotiazepam
• Synonyms: 5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno[2,3-e]-1,4-diazepin-2-one, 2H-Thieno[2,3-e]-1,4-diazepin-2-one, 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl- (8CI), 1-Methyl-5-o-chlorophenyl-7-ethyl-1,2-dihydro-3H-thieno[2,3-e][1,4]diazepin-2-one, 5-(2-Chlorophenyl)-7-ethyl-1-methyl-1H-thieno[2,3-e][1,4]diazepin-2(3H)-one, 5-(o-Chlorophenyl)-7-ethyl-1-methyl-1,2-dihydro-3H-thieno[2,3-e][1,4]diazepin-2-one, Clozan, Rize, Rizen, Tienor, Trecalmo, Veratran, Y 6047, 2H-Thieno[2,3-e]-1,4-diazepin-2-one, 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
• CAS: 33671-46-4

Description

Applications A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to benzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor. Controlled Substance.
References Mandrioli, R. et al.: Curr.Drug Metab., 8, 827 (2008); Nakazawa, Y. et al.: Psychopharmacol., 44, 165 (1975); Yakushiji, T. et al.: Br. J. Pharmacol., 98, 735 (1989);

• Brand: TRC

Chemical properties

• Molecular weight: 318.82
• Formula: C₁₆H₁₅ClN₂OS
• Color/Form: Off-White
• InChI: InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3
• InChI key: InChIKey=CHBRHODLKOZEPZ-UHFFFAOYSA-N
• SMILES: CCc1cc2c(s1)N(C)C(=O)CN=C2c1ccccc1Cl