Product Information
Name:1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole
Controlled Product
Synonyms:
- 1-Chloro-3-(2-nitroimidazol-1-yl)propan-2-ol
- Ro 07-0269
- α-(Chloromethyl)-2-nitro-1H-imidazole-1-ethanol
Brand:TRC
Description:Applications 1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole is an intermediate in the synthesis of 1-(2,3-Epoxypropyl)-2-nitroimidazole (B592583) which is an intermediate in the synthesis of Pimonidazole-d10 (P447814). Isotope labelled Pimonidazole (P447813) is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It abels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.References Sato et al.: PLoS One 11 e0165946 PMID:(2016); Bennewith et al.: Cancer Res. 62 6827 PMID: 12460894, (2002)
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Chemical properties
Molecular weight:205.599
Formula:C6H8ClN3O3
Color/Form:Neat
InChI:InChI=1S/C6H8ClN3O3/c7-3-5(11)4-9-2-1-8-6(9)10(12)13/h1-2,5,11H,3-4H2
SMILES:O=[N+]([O-])c1nccn1CC(O)CCl
Technical inquiry about: 1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole
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