4-(2-Chlorophenyl)-2-methyl-5-oxo-4,4a,5,7,8,10-hexahydro-1H-pyrido[2',3':2,3]azeto[2,1-c][1,4]oxazine-3-carboxylic Acid

Ref. TR-C609788

Product Information

• Name: 4-(2-Chlorophenyl)-2-methyl-5-oxo-4,4a,5,7,8,10-hexahydro-1H-pyrido[2',3':2,3]azeto[2,1-c][1,4]oxazine-3-carboxylic Acid
• Synonyms: 5-(2-chlorophenyl)-3-methyl-7-oxo-11-oxa-2,8-diazatricyclo[6.4.0.01,6]dodec-3-ene-4-carboxylic acid
• Brand: TRC
• Description: Applications 4-(2-Chlorophenyl)-2-methyl-5-oxo-4,4a,5,7,8,10-hexahydro-1H-pyrido[2',3':2,3]azeto[2,1-c][1,4]oxazine-3-carboxylic Acid is an intermediate in the synthesis of 3-O-Desethyl-5-O-desmethyl Amlodipine (D291305). 3-O-Desethyl-5-O-desmethyl Amlodipine is an impurity of Amlodipine (A633495), which is a dihydropyridine calcium channel blocker.References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995)

Chemical properties

• Molecular weight: 348.781
• Formula: C₁₇H₁₇ClN₂O₄
• Color/Form: Neat
• InChI: InChI=1S/C17H17ClN2O4/c1-9-12(16(22)23)13(10-4-2-3-5-11(10)18)14-15(21)20-6-7-24-8-17(14,20)19-9/h2-5,13-14,19H,6-8H2,1H3,(H,22,23)
• InChI key: InChIKey=NHBISDQQKVTVJD-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)O)C(c2ccccc2Cl)C2C(=O)N3CCOCC23N1