Product Information
Name:Colchicine Methanethiosulfonate
Controlled Product
Synonyms:
- 3-Methylsulfonylsulfanyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]propanamide
Brand:TRC
Description:Applications The methanethiosulfonate derfivative of Colchicine (C640000), an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:511.61
Formula:C22H25NO6·CH4O2S2
Color/Form:Neat
InChI:InChI=1S/C22H25NO6.CH4O2S2/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16;1-5(2,3)4/h7,9-11,16H,6,8H2,1-5H3,(H,23,24);1H3,(H,2,3,4)/t16-;/m0./s1
InChI key:InChIKey=KZMCZFBQMMHSRF-KRWDZBQOSA-N
SMILES:COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1[C@@H](NC(=O)CCSS(C)(=O)=O)CC2
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