α-Cortolone

CAS: 516-42-7

Ref. TR-C696280

Product Information

• Name: α-Cortolone
• Synonyms: 3α,17,20α,21-Tetrahydroxy-5β-pregnan-11-one, 20α-Cortolone, 3α,17,20α,21-Tetrahydroxy-5β-pregnan-11-one, 3α,17α,20α,21-Tetrahydroxy-5β-pregnan-11-one, 5β-Pregnan-3α,17α,20α,21-tetrol-11-one, 5β-Pregnane-3α,17,20α,21-tetrol-11-one, 5β-Pregnane-3α,17α,20α,21-tetrol-11-one, Cortolon, Cortolone, NSC 59872
• Brand: TRC
• Description: Applications α-Cortolone is a human urinary metabolite of Cortisol ((H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.References Yergey, A.L., et. al.: Steroids, 60, 295 (1995); Vigore, L., et al.: Cancer Ther., 6, 699 (2008); Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009); Lemos, D., et al.: J. Endocrinol., 201, 275 (2009); Chen, S., et al.: Am. J. Physiol., 296 (2009)

Chemical properties

• Molecular weight: 366.49
• Formula: C₂₁H₃₄O₅
• Color/Form: Neat
• InChI: InChI=1S/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,17-18,22-23,25-26H,3-11H2,1-2H3/t12-,13-,14+,15+,17+,18-,19+,20+,21+/m1/s1
• InChI key: InChIKey=JXCOSKURGJMQSG-GVLPUTKTSA-N
• SMILES: C[C@]12CC[C@@H](O)CC1CC[C@@H]1[C@@H]2C(=O)C[C@@]2(C)[C@H]1CC[C@]2(O)[C@@H](O)CO