(4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester

CAS: 125971-94-0

Ref. TR-C982020

Product Information

• Name: (4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester
• Synonyms: 1,3-Dioxane-4-acetic acid, 6-(cyanomethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-, : 1,3-Dioxane-4-acetic acid, 6-(cyanomethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R-cis)-, ((4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester, (6R-Cyanomethyl-2,2-dimethyl-[1,3]dioxan-4R-yl)acetic acid tert-butyl ester, (4R,3R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, (4R,6R)-Tert-Butyl-6-Cyanomethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate, (4R,6R)-t-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, (4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate (ATS-8), (4R,Cis)-1,1-dimethylethyl-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, (4R-cis)-1,1-Dimethylethyl-6-Cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, (4R-cis)-1,1-Dimethylethyl-6-Cyanomethyl-2,2-dlmethyl-1,3-dioxane-4-acetate, 1,1-Dimethylethyl (4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetate, 1,3-Dioxane-4-acetic acid, 6-(cyanomethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-, 1,3-Dioxane-4-acetic acid, 6-(cyanomethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R-cis)-, ATS-8(for Atorvastatin), Ast-8, Atorvastatin Calcium Intermediate ATS-8, AtorvastatinCalcium(ATS-8), Ats-8, Tert-Butyl (4R,3R)-6-Cyanomethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate, Tert-Butyl 2-((4R,6R)-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl) acetate, tert-Butyl(3R,5R)-6-cyano-3,5-O-iso-propylidene-3,5-dihydroxyhexanoate, tert-butyl [(4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Description

Applications (4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester is an intermediate of Atorvastatin (A791750, Ca salt), a selective, competitive HMG-CoA reductase . Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),

• Brand: TRC

Chemical properties

• Molecular weight: 269.34
• Formula: C₁₄H₂₃NO₄
• Color/Form: Neat
• InChI: InChI=1S/C14H23NO4/c1-13(2,3)19-12(16)9-11-8-10(6-7-15)17-14(4,5)18-11/h10-11H,6,8-9H2,1-5H3/t10-,11-/m1/s1
• InChI key: InChIKey=VVGMLAZGNPEIRZ-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CC1CC(CC#N)OC(C)(C)O1